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A picture of a 4-camera panoramic optical mapping system during an
experimental run. An illuminated adult pig heart is visible at the center
of the picture.
experimental run. An illuminated adult pig heart is visible at the center
of the picture.
Normalized fluorescence action potential signals
from the anterior (Camera 1), left lateral (Camera 2),
posterior (Camera 3) and right lateral (Camera 4)
points-of-view of a pig heart during electrical pacing,
taken from the blue-square regions shown. The red
circle indicates the location of electrical point
stimulation.
from the anterior (Camera 1), left lateral (Camera 2),
posterior (Camera 3) and right lateral (Camera 4)
points-of-view of a pig heart during electrical pacing,
taken from the blue-square regions shown. The red
circle indicates the location of electrical point
stimulation.
Normalized fluorescence intensity map (colorbar shown) at one time point during
ventricular fibrillation.
ventricular fibrillation.
What We Do
Sample Project 1:
- Work closely with colleagues to create detailed system specifications
- Perform proof-of-principle experiments at the research or teaching laboratory with prototype systems,
from which results can be used as supporting data for grant applications
- Use parallel design paths and perform frequent experimental tests to minimize development time and risk
- Collaborate on academic projects by helping design and perform experiments
- Analyze data from experiments and assist in drafting manuscripts
Economical Panoramic Optical Mapping Systems for Studying Complex Arrhythmias
(Multi-View High-Speed Fluorescence Imaging)
(Multi-View High-Speed Fluorescence Imaging)
Client:
Spanish National Cardiovascular Research Center (CNIC)
Madrid, Spain
Spanish National Cardiovascular Research Center (CNIC)
Madrid, Spain
Sample Project 2:
Multi-Parametric Electrophysiological Imaging Platform for Testing Drug Effects
(Experimental Model: Human iPS-Cell-Derived Cardiac Tissue Constructs)
(Experimental Model: Human iPS-Cell-Derived Cardiac Tissue Constructs)
Client:
Roche Pharma Research and Early Development
F. Hoffmann-La Roche Ltd
Basel, Switzerland
Roche Pharma Research and Early Development
F. Hoffmann-La Roche Ltd
Basel, Switzerland
Related Manuscript:
Lee, P. et al. Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and
Drug-Action in Translational Heart Models. Sci. Rep. 7, 43217; doi: 10.1038/srep43217 (2017).
Lee, P. et al. Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and
Drug-Action in Translational Heart Models. Sci. Rep. 7, 43217; doi: 10.1038/srep43217 (2017).
Simultaneous measurement of action potentials and ratiometric calcium transients during
electrical pacing, taken from the blue-square region shown. Conduction velocity and
contractility/force measurements are also possible with the experimental model shown.
electrical pacing, taken from the blue-square region shown. Conduction velocity and
contractility/force measurements are also possible with the experimental model shown.
Sample results from drug testing, using the same experimental model.